36. Wang, X.*; Zhang, Y.; Hutchinson, M. R.; Rice, K. C.; Yin, H.; Watkins, L. R. (2015) Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists.Br. J. Pharmacol., 172, in reviewing. (*Corresponding author)
35. Grace, P.; Wang, X.; Urban, D.; Baratta, M.; Galer, E.; Strand, K.; Zhang, Y.; Yin, H.; Roth, B.; Maier, S.; Watkins, L. R.(2015) Selective manipulation of spinal microglia by chemogenetics: implications for allodynia and inflammatory signaling. J. Pain,4 , S38.
34. Selfridge, B. R. #; Wang, X. #; Zhang, Y.; Yin, H.; Watkins, L. R.; Jacobson, A. E.; Rice, K. C. (2015)Structure activity relationships of (+)-naltrexone-inspired Toll-like receptor 4 (TLR4) antagonists. J. Med. Chem., 58,58,5038-5052.(#These authors contribute equally to this work)
33. Smith, C. #; Wang, X. # ; Yin, H. (2015)Caspases come together. Trends Immunol., 36, 59-61. (#These authors contribute equally to this work)
32. Wang, X.; Wang, X.; Feng, Y.; Zhu, M.; Yin, H.; Guo, Q.; Meng, X. (2015)A two-photon fluorescent probe for detecting endogenous hypochlorite in living cells.Dalton Trans., 44, 6613-6619.
31. Yang, H. #; Chen, Y. Z. #; Zhang, Y. #; Wang, X.; Zhao, X.; Godfroy, J. I.; Lian, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.; Yin, H.; Xue, D. (2015) A Lysin-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat. Commun., 6, 5717. (# These authors contribute equally to this work)
30.Bachtell, R.; Hutchinson, M. R.; Wang, X. ; Rice, K. C.; Maier, S. F,; Watkins, L. R. (2015) Targeting the Toll of drug abuse: the translational potential of Toll-like receptor 4. CNS Neurol. Disord. Drug Targets., 14, 692-699.
29. Northcutt, A. L.; Hutchinson, M. R. #; Wang, X. #; Baratta, M.; Hiranita, T.; Cochran, T.; Pomrenze, M.; Galer, E.; Kopajtic, R.; Li, C. M.; Amat, J.; Larson, G.; Cooper, D.; Huang, Y.; O'Neil, C.; Yin, H.; Zahniser, N.; Katz, J.; Rice, K. C.; Maier, S. F.; Bachtell, R.; Watkins, L.R. (2015)DAT isn't all that: cocaine reward and reinforcement requires Toll like receptor 4 signaling. Mol. Psychiatry (NPG), 20, in press (DOI: 10.1038/mp.2014.177). (#These authors contribute equally to this work)
28. Grace, P. M.; Ramos, K. M.; Rodgers, K. M.; Wang, X.; Hutchinson, M. R.; Lewis M. T.; Morgan, K. N.; Kroll, J. L.; Taylor, F. R.; Strand, K. A.; Zhang, Y.; Berkelhammer, D.; Huey, M.; Greene, L. I.; Cochran, T. A.; Yin, H.; Barth, D. S.; Johnson, K. W.; Rice, K.; Maier, S. F.; Watkins, L. R. (2014) Activation of adult rat CNS endothelial cells by opioid-induced TLR4 signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae, Neuroscience, 280, 299-317.
27. Wang, X., Cochran, T.A.; Hutchinson, M. R.; Yin, H.; Watkins, L. R. (2014) “Drug abuse” in Microglia in health and disease (Sierra, A.; Tremblay, M. E. Ed.), Springer-Verlag (Berlin Heidelberg), 299-317.
26. Watkins, L. R., Wang, X., Mustafa, S., Hutchinson, M. R. (2014) In vivo veritas:(+)-naltrexone's actions define translational importance, Trends Pharmacol. Sci., 35, 432-433
25. Wang, X., Smith, C.; Yin, H. (2013) Targeting Toll-like receptors with small molecule agents, Chem. Soc. Rev., 42, 4859-4866. (Cover article)
24. Wang, X.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C.; Li, J.; Watkins, L. R.; Yin, H. (2013)Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain, FASEB J. , 27, 2713-2722
23. Li, J. #; Wang, X. #; Zhang, F.; Yin, H (2013) Toll-like receptors as the therapeutic targets of autoimmune connective tissue diseases, Pharmacol. Ther., 138, 441-445 (#These authors contribute equally to this work)
22. Wang, X.; Saludes, J. P.; Zhao, T. X.; Csakai, A.; Fiorini, Z.; Chavez, S. A.; Li, J.; Lee, G. I.; Varga, K.; Yin, H. (2012) Targeting the lateral interactions of transmembrane domain 5 of Epstein–Barr virus latent membrane protein 1, Biochim. Biophys. Acta-Biomembranes, 1818, 2282-2289. (This research has been highlighted by NewsRx, the world’s largest producer of health news.)
21. Wang, X.; Fiorini, Z.; Smith T.; Zhang, Y.; Li, J.; Watkins, L. R.; Yin, H. (2012)Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1, PLoS One, e47703
20. Wang, X.;Loram, L.C.; Ramos, K.; de Jesus, A. J.; Jacob, A. J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.; Yin, H. (2012)Morphine activates neuroinflammataion in a parallel manner to endotoxin, Proc. Natl. Acad. Sci. USA, 109, 6325-6330. (This work has been highlighted by Nature, PNAS, Science Signaling (Editors’ choice), Faculty of 1000, American Association of Universities, Science Daily, Colorado Daily and several other media; One-line impact: Top 6% compared to articles of the same age)
19. Cheng, K.; Wang, X.; Zhang, S.;Yin, H. (2012) Discovery of small molecule inhibitors of the TLR1-TLR2 complex, Angew. Chem. Int. Edit. 51, 12246-12249. (Cover article, highlighted by C&EN)
18. Zhang, S.; Cheng, K.; Wang, X.; Yin, H. (2012) Selection, synthesis, and antiinflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitor, Bioorg. Med. Chem., 20, 6073-6079. (Cover article).
17. Hutchinson, M. R.; Northcutt, A. L.; Hiranita, T.; Wang, X.; Lewis, S.; Kopajtic, T. A.; Loram, L.; Sfregola, C.; Galer, E.; Miles, N. E.; Bland, S. T.; Amat, J.; Rozeske, R. R.; Maslanik, T.; Chapman, T.; Strand, K.; Fleshner, M.; Bachtell, R. K.; Yin, H. J.; Katz, L.; Rice, K. C.; Maier, S. F.; Watkins, L. R. (2012)Opioid activation of Toll-Like receptor 4 contributes to drug reinforcement, J. Neurosci., 32, 11187-11200. (This work has been highlighted by Washington Post, Newscientist, Asianscientist and several other media)
16. Cheng, K.; Wang, X.; Yin, H. (2011) Small molecule inhibitors of the TLR3/dsRNA complex, J. Am. Chem. Soc., 133, 3764-3767.
15. Wang, X.; Qu, K.; Xu, B.; Ren, J.; Qu, X. (2011) Microwave assisted one-step green synthesis of multicolor photoluminescent carbon dots without surface passivation reagents, J. Mater. Chem., 21, 2445-2450.
14.Wang, X.; Qu, K.; Xu, B.; Ren, J.; Qu, X. (2011)Multicolor luminescent carbon nanoparticles: synthesis, supramolecular assembly with porphyrin, intrinsic peroxidase-like catalytic activity and application, Nano Res., 4, 908-920. (This research has been featured byLife Science Weekly)
13. Wang, X.; Ren, J.; Miyoshi, D.; Sugimoto, N.; Qu, X. (2011) Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe, Biosens. Bioelectron., 26, 4804-4809.
12. Wang, X.; Chen, Y.; Ren, J.; Qu, X. (2011) Small interfering RNA for effective cancer therapies, Mini. Rev. Med. Chem., 11, 114-124.
11. Song, Y.; Wang, X.; Zhao, C.; Qu, K.; Ren, J.; Qu, X. (2010) Label-free colorimetric detection of single nucleotide polymorphism by using single-walled carbon nanotube intrinsic peroxidase-like activity, Chem. Eur. J., 16, 3617-3621.
10. Wang, X.; Geng, J.; Miyoshib,D.; Ren, J.; Sugimoto, N.; Qu, X. (2010) A rapid and sensitive “add-mix-measure” assay for multiple proteinases based on one gold nanoparticle–peptide–fluorophore conjugate, Biosens. Bioelectron.,26, 743-747.
9. Wang, X.; Wang, C.; Qu, K.; Song, Y.; Ren, J.; Miyoshi, D.; Sugimoto, N.; Qu, X. (2010). Ultrasensitive and selective detection of a prognostic indicator in early-stage cancer using graphene oxide and carbon nanotubes, Adv. Funct. Mater., 20, 3967-3971. (Inner cover article; This work has been highlighted by WILEY-VCH Materials Views China, the leading nanotechnology website Nanowerk and several other media)
8. Peng, Y.; Wang, X.; Xiao, Y.; Feng, L.; Zhao, C.; Ren. J.; Qu, X. (2009) An i-motif quadruplex DNA-based biosensor for distinguishing single- and multi-walled carbon nanotubes, J. Am. Chem. Soc., 131, 13813-13818.
7. Wang, X.; Song, Y.; Ren, J.; Qu, X. (2009) Knocking-down cyclin A2 by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin, PLoS One, 4, e6665.6
6. Yu, H.; Wang, X.; Fu, M.; Ren, J.; Qu, X. (2008) Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA,Nucleic Acids Res., 36, 5695-5703.
5. Shi, Q.; Wang, X.; Ren, J. (2008) Biophysical characterization of the interaction of p21 with calmodulin: a mechanistic study, Biophys. Chem., 138, 138-143.
4. Wang, X.; Ren, J.; Qu, X. (2008) Targeted RNA interference of cyclin A2 mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells, ChemMedChem, 3, 940-945. (It is one of the most cited papers ChemMedChem published in 2008/2009)
3. Wang, X.; Ren, J.; Qu, X. (2008) Biophysical studies on the full-length human cyclin A2: protein stability and folding/unfolding thermodynamics, J. Phys. Chem. B, 112, 8346-8353.
2. Bao, H.; Wang, X.; Yu, H.; Fu, M.; Qu, X.; Zheng, Y.; Ren, J. (2007) Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs, Chem. Phys. Lett., 436, 252-257.
1. Wang, X.; Fu, M.; Ren, J.; Qu, X. (2007) Evaluation of different culture conditions for high-level soluble expression of human cyclin A2 with pET vector in BL21 (DE3) and spectroscopic characterization of its inclusion body structure, Protein Expr. Purif., 56, 27-34.
